Summary of an International Symposium on phenytoin-induced teratology and gingival pathology.
نویسندگان
چکیده
Phenytoin has been the preferred drug for treating grand mal epilepsy for more than 40 years. The metabolism of this drug, its teratogenic potential, and its role in the pathogenesis of gingival overgrowth are discussed.
منابع مشابه
Immunohistochemical Analysis of the Role Connective Tissue Growth Factor in Drug-induced Gingival Overgrowth in Response to Phenytoin, Cyclosporine, and Nifedipine
Objective To evaluate for the presence of connective tissue growth factor (CTGF) in drug (phenytoin, cyclosporine, and nifedipine)-induced gingival overgrowth (DIGO) and to compare it with healthy controls in the absence of overgrowth. Materials and Methods Thirty-five patients were chosen for the study and segregated into study (25) and control groups (10). The study group consisted of pheny...
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BACKGROUND AND AIM: The aim of this study was to evaluate the effect of topical phenytoin on creeping attachment. METHODS: In this pilot quasi-experimental study, 8 patients referring to Kerman School of Dentistry, Kerman, Iran with Miller class I or II gingival recessions were selected using convenient non-random sampling if they needed root coverage and met the study's inclusion criteria. The...
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Phenytoin is one of the most widely prescribed antiepileptic drugs (AEDs) in the USA (approximately 52% of AED prescriptions compared with 19% for valproic acid, 11% carbamazepine, and 7% phenobarbital) [1]. It has a narrow therapeutic range and wide interindividual variability in clearance and, as such, therapeutic drug monitoring is often necessary. Adverse effects of phenytoin range from min...
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Context: Gingival overgrowth can be associated with pharmacotherapy. Among the offending medications of gingival overgrowth, phenytoin is the first reported and the most common agent. Evidence Acquisition: A literature search was performed with the relevant key words in different databases such as Scopus, Medline, Embase, and Google scholar. Results: About 50% of individuals receiving phenytoin...
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This article has summarized observations and results of controlled laboratory and clinical studies of drug-induced gingival hyperplasia associated with phenytoin, cyclosporine, and nifedipine use. Furthermore, information regarding the pharmacologic aspects of these medications is presented. More information is needed for a greater understanding of drug-induced gingival hyperplasia. It appears ...
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ورودعنوان ژورنال:
- Journal of the American Dental Association
دوره 99 4 شماره
صفحات -
تاریخ انتشار 1979